Some polar ionic pesticides and their associated metabolites are not “amenable” to common multi residue methods, such as QuEChERS. These compounds need alternative extraction conditions for improved recovery and/or alternative separation conditions for improved retention and/or peak shape. Currently the polar pesticides tend to be treated as a series of selective single residue methods adding significant cost to the analysis and therefore, are often excluded from pesticide monitoring programs. At Fera we have coupled the QuPPe generic extraction conditions with determination by suppressed ion chromatography tandem quadrupole mass spectrometry. This presentation will describe our experiences and challenge faced in implementing this method, presenting validation data in a cereals matrix. View the presentation here.